activated factor x การใช้

• Factor IX when activated activates factor X which helps fibrinogen to fibrin conversion.
• This complex ( in the coagulation pathway ) will eventually activate factor X.
• Factor IXa, in turn, activates factor X.
• The combination activates factor X to factor Xa and factor IX to factor IXa.
• This binding leads to a conformational change of AT which accelerates its inhibition of activated factor X ( factor Xa ).
• The coagulant in the venom directly activates factor X, which turns prothrombin into thrombin in the presence of factor V and phospholipid.
• Factor VIII, on the other hand, is a cofactor in production of activated Factor X, which in turn converts prothrombin into thrombin.
• Once dissociated, the LMWH is free to bind to another antithrombin molecule and subsequently inhibit more activated factor X . Unlike AT activated by Heparin, AT activated by LMWH cannot inhibit thrombin, but can only inhibit clotting factor Xa.
• The thereby activated factor V ( now called FVa ) is a cofactor of the prothrombinase complex : The activated factor X ( FXa ) enzyme requires calcium and activated factor V to convert prothrombin to thrombin on the cell surface membrane.